Ion Channelopathy Clinic-Sudden Death Genomics: An Impromptu Diagnosis
نویسندگان
چکیده
منابع مشابه
Genomics in sudden cardiac death.
Sudden cardiac death (SCD) remains a public health problem of major magnitude. Contrary to earlier expectations, and despite decreased overall cardiac mortality, SCD rates appear to be rising in concert with escalating global prevalence of coronary disease and heart failure, the two major conditions predisposing to SCD. With the exception of the implantable defibrillator, there are few effectiv...
متن کاملSudden cardiac death and inherited channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease
Mutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and clinical risk stratification and treatment consequently limited. Basic research using molecular techniques...
متن کاملIon Channel Disorders and Sudden Cardiac Death
Long QT syndrome, short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia are inherited primary electrical disorders that predispose to sudden cardiac death in the absence of structural heart disease. Also known as cardiac channelopathies, primary electrical disorders respond to mutations in genes encoding cardiac ion channels and/or their regulatory protei...
متن کاملDiagnosis and management of sudden cardiac death.
Correspondence to: Peter S Spector, MD, Cardiac Electrophysiology Laboratories, University of Vermont College of Medicine/Fletcher Allen Health Care, Cardiology Department, McClure 1, 111 Colchester Avenue, Burlington, VT 05401, USA; [email protected] _________________________ S udden cardiac death (SCD) is an enormous public health problem with at least 300 000 deaths per year in the ...
متن کاملSkeletal muscle channelopathy: a new risk for sudden infant death syndrome
www.thelancet.com Published online March 28, 2018 http://dx.doi.org/10.1016/S0140-6736(18)30477-X 1 Sudden infant death syndrome (SIDS) remains a leading cause of infant mortality, despite a steadily decreasing incidence since the 1990s. The reasons for this decline are debated, but it could be due to methodological reasons (eg, changes in reporting or advances in diagnosis of specific diseases...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cardiology & Cardiovascular Therapy
سال: 2018
ISSN: 2474-7580
DOI: 10.19080/jocct.2018.11.555817